Resistance of THP-1 Leukemia Cells Infected with Cytomegalovirus to Anti-tumor Antibiotic Doxorubicin and Restoration of the Sensitivity by Inhibitors of the PI3K/AKT/mTOR Molecular Pathway.
Identifieur interne : 000244 ( Main/Exploration ); précédent : 000243; suivant : 000245Resistance of THP-1 Leukemia Cells Infected with Cytomegalovirus to Anti-tumor Antibiotic Doxorubicin and Restoration of the Sensitivity by Inhibitors of the PI3K/AKT/mTOR Molecular Pathway.
Auteurs : Ya Yu Chernoryzh [Russie] ; N E Fedorova [Russie] ; K I Yurlov [Russie] ; R A Simonov [Russie] ; A B Kornev [Russie] ; D S Karpov [Russie] ; N F Zakirova [Russie] ; A V Ivanov [Russie] ; A A Kushch [Russie] ; A L Gintsburg [Russie]Source :
- Doklady. Biochemistry and biophysics [ 1608-3091 ] ; 2019.
Descripteurs français
- KwdFr :
- Antibiotiques antinéoplasiques (pharmacologie), Cellules THP-1 (MeSH), Cytomegalovirus (physiologie), Doxorubicine (pharmacologie), Humains (MeSH), Leucémies (anatomopathologie), Phosphatidylinositol 3-kinases (métabolisme), Protéines proto-oncogènes c-akt (métabolisme), Résistance aux médicaments antinéoplasiques (effets des médicaments et des substances chimiques), Sirolimus (pharmacologie), Survie cellulaire (effets des médicaments et des substances chimiques), Synergie des médicaments (MeSH), Sérine-thréonine kinases TOR (métabolisme).
- MESH :
- anatomopathologie : Leucémies.
- effets des médicaments et des substances chimiques : Résistance aux médicaments antinéoplasiques, Survie cellulaire.
- métabolisme : Phosphatidylinositol 3-kinases, Protéines proto-oncogènes c-akt, Sérine-thréonine kinases TOR.
- pharmacologie : Antibiotiques antinéoplasiques, Doxorubicine, Sirolimus.
- physiologie : Cytomegalovirus.
- Cellules THP-1, Humains, Synergie des médicaments.
English descriptors
- KwdEn :
- Antibiotics, Antineoplastic (pharmacology), Cell Survival (drug effects), Cytomegalovirus (physiology), Doxorubicin (pharmacology), Drug Resistance, Neoplasm (drug effects), Drug Synergism (MeSH), Humans (MeSH), Leukemia (pathology), Phosphatidylinositol 3-Kinases (metabolism), Proto-Oncogene Proteins c-akt (metabolism), Sirolimus (pharmacology), THP-1 Cells (MeSH), TOR Serine-Threonine Kinases (metabolism).
- MESH :
- chemical , metabolism : Proto-Oncogene Proteins c-akt, TOR Serine-Threonine Kinases.
- chemical , pharmacology : Antibiotics, Antineoplastic, Doxorubicin, Sirolimus.
- drug effects : Cell Survival, Drug Resistance, Neoplasm.
- metabolism : Phosphatidylinositol 3-Kinases.
- pathology : Leukemia.
- physiology : Cytomegalovirus.
- Drug Synergism, Humans, THP-1 Cells.
Abstract
Results obtained showed that infection with HCMV prevented the death of THP-1 cells treated with DOX in both active and latent forms of infection. In the presence of mTOR inhibitors (rapamycin and Torin2), the sensitivity of the infected cells to DOX was restored. Rapamycin inhibited the expression of the HCMV protein IE1-p72 and increased sensitivity to DOX. Molecular targets for the creation of new drugs for the treatment of leukemia in patients infected with HCMV were determined.
DOI: 10.1134/S1607672919060073
PubMed: 32130607
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Gamaleya National Research Center for Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Fedorova, N E" sort="Fedorova, N E" uniqKey="Fedorova N" first="N E" last="Fedorova">N E Fedorova</name><affiliation wicri:level="3"><nlm:affiliation>Gamaleya National Research Center for Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Gamaleya National Research Center for Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Yurlov, K I" sort="Yurlov, K I" uniqKey="Yurlov K" first="K I" last="Yurlov">K I Yurlov</name><affiliation wicri:level="3"><nlm:affiliation>Gamaleya National Research Center for Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Gamaleya National Research Center for Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Simonov, R A" sort="Simonov, R A" uniqKey="Simonov R" first="R A" last="Simonov">R A Simonov</name><affiliation wicri:level="3"><nlm:affiliation>Gamaleya National Research Center for Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Gamaleya National Research Center for Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Kornev, A B" sort="Kornev, A B" uniqKey="Kornev A" first="A B" last="Kornev">A B Kornev</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow oblast, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow oblast</wicri:regionArea><wicri:noRegion>Moscow oblast</wicri:noRegion></affiliation></author><author><name sortKey="Karpov, D S" sort="Karpov, D S" uniqKey="Karpov D" first="D S" last="Karpov">D S Karpov</name><affiliation wicri:level="3"><nlm:affiliation>Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Zakirova, N F" sort="Zakirova, N F" uniqKey="Zakirova N" first="N F" last="Zakirova">N F Zakirova</name><affiliation wicri:level="3"><nlm:affiliation>Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Ivanov, A V" sort="Ivanov, A V" uniqKey="Ivanov A" first="A V" last="Ivanov">A V Ivanov</name><affiliation wicri:level="3"><nlm:affiliation>Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Kushch, A A" sort="Kushch, A A" uniqKey="Kushch A" first="A A" last="Kushch">A A Kushch</name><affiliation wicri:level="3"><nlm:affiliation>Gamaleya National Research Center for Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia. vitallku@mail.ru.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Gamaleya National Research Center for Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Gintsburg, A L" sort="Gintsburg, A L" uniqKey="Gintsburg A" first="A L" last="Gintsburg">A L Gintsburg</name><affiliation wicri:level="3"><nlm:affiliation>Gamaleya National Research Center for Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Gamaleya National Research Center for Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>The First Sechenov Moscow State Medical University under Ministry of Health of the Russian Federation, Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>The First Sechenov Moscow State Medical University under Ministry of Health of the Russian Federation, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author></analytic><series><title level="j">Doklady. Biochemistry and biophysics</title><idno type="eISSN">1608-3091</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antibiotics, Antineoplastic (pharmacology)</term><term>Cell Survival (drug effects)</term><term>Cytomegalovirus (physiology)</term><term>Doxorubicin (pharmacology)</term><term>Drug Resistance, Neoplasm (drug effects)</term><term>Drug Synergism (MeSH)</term><term>Humans (MeSH)</term><term>Leukemia (pathology)</term><term>Phosphatidylinositol 3-Kinases (metabolism)</term><term>Proto-Oncogene Proteins c-akt (metabolism)</term><term>Sirolimus (pharmacology)</term><term>THP-1 Cells (MeSH)</term><term>TOR Serine-Threonine Kinases (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Antibiotiques antinéoplasiques (pharmacologie)</term><term>Cellules THP-1 (MeSH)</term><term>Cytomegalovirus (physiologie)</term><term>Doxorubicine (pharmacologie)</term><term>Humains (MeSH)</term><term>Leucémies (anatomopathologie)</term><term>Phosphatidylinositol 3-kinases (métabolisme)</term><term>Protéines proto-oncogènes c-akt (métabolisme)</term><term>Résistance aux médicaments antinéoplasiques (effets des médicaments et des substances chimiques)</term><term>Sirolimus (pharmacologie)</term><term>Survie cellulaire (effets des médicaments et des substances chimiques)</term><term>Synergie des médicaments (MeSH)</term><term>Sérine-thréonine kinases TOR (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Proto-Oncogene Proteins c-akt</term><term>TOR Serine-Threonine Kinases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antibiotics, Antineoplastic</term><term>Doxorubicin</term><term>Sirolimus</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Leucémies</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Survival</term><term>Drug Resistance, Neoplasm</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Résistance aux médicaments antinéoplasiques</term><term>Survie cellulaire</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Phosphatidylinositol 3-Kinases</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Phosphatidylinositol 3-kinases</term><term>Protéines proto-oncogènes c-akt</term><term>Sérine-thréonine kinases TOR</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Leukemia</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antibiotiques antinéoplasiques</term><term>Doxorubicine</term><term>Sirolimus</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Cytomegalovirus</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cytomegalovirus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Drug Synergism</term><term>Humans</term><term>THP-1 Cells</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Cellules THP-1</term><term>Humains</term><term>Synergie des médicaments</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Results obtained showed that infection with HCMV prevented the death of THP-1 cells treated with DOX in both active and latent forms of infection. In the presence of mTOR inhibitors (rapamycin and Torin2), the sensitivity of the infected cells to DOX was restored. Rapamycin inhibited the expression of the HCMV protein IE1-p72 and increased sensitivity to DOX. Molecular targets for the creation of new drugs for the treatment of leukemia in patients infected with HCMV were determined.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32130607</PMID><DateCompleted><Year>2020</Year><Month>05</Month><Day>12</Day></DateCompleted><DateRevised><Year>2020</Year><Month>05</Month><Day>18</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1608-3091</ISSN><JournalIssue CitedMedium="Internet"><Volume>489</Volume><Issue>1</Issue><PubDate><Year>2019</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Doklady. Biochemistry and biophysics</Title><ISOAbbreviation>Dokl Biochem Biophys</ISOAbbreviation></Journal><ArticleTitle>Resistance of THP-1 Leukemia Cells Infected with Cytomegalovirus to Anti-tumor Antibiotic Doxorubicin and Restoration of the Sensitivity by Inhibitors of the PI3K/AKT/mTOR Molecular Pathway.</ArticleTitle><Pagination><MedlinePgn>388-391</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1134/S1607672919060073</ELocationID><Abstract><AbstractText>Results obtained showed that infection with HCMV prevented the death of THP-1 cells treated with DOX in both active and latent forms of infection. In the presence of mTOR inhibitors (rapamycin and Torin2), the sensitivity of the infected cells to DOX was restored. Rapamycin inhibited the expression of the HCMV protein IE1-p72 and increased sensitivity to DOX. Molecular targets for the creation of new drugs for the treatment of leukemia in patients infected with HCMV were determined.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chernoryzh</LastName><ForeName>Ya Yu</ForeName><Initials>YY</Initials><AffiliationInfo><Affiliation>Gamaleya National Research Center for Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fedorova</LastName><ForeName>N E</ForeName><Initials>NE</Initials><AffiliationInfo><Affiliation>Gamaleya National Research Center for Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yurlov</LastName><ForeName>K I</ForeName><Initials>KI</Initials><AffiliationInfo><Affiliation>Gamaleya National Research Center for Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Simonov</LastName><ForeName>R A</ForeName><Initials>RA</Initials><AffiliationInfo><Affiliation>Gamaleya National Research Center for Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kornev</LastName><ForeName>A B</ForeName><Initials>AB</Initials><AffiliationInfo><Affiliation>Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow oblast, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Karpov</LastName><ForeName>D S</ForeName><Initials>DS</Initials><AffiliationInfo><Affiliation>Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zakirova</LastName><ForeName>N F</ForeName><Initials>NF</Initials><AffiliationInfo><Affiliation>Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ivanov</LastName><ForeName>A V</ForeName><Initials>AV</Initials><AffiliationInfo><Affiliation>Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kushch</LastName><ForeName>A A</ForeName><Initials>AA</Initials><AffiliationInfo><Affiliation>Gamaleya National Research Center for Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia. vitallku@mail.ru.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gintsburg</LastName><ForeName>A L</ForeName><Initials>AL</Initials><AffiliationInfo><Affiliation>Gamaleya National Research Center for Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>The First Sechenov Moscow State Medical University under Ministry of Health of the Russian Federation, Moscow, Russia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>03</Month><Day>04</Day></ArticleDate></Article><MedlineJournalInfo><Country>Russia (Federation)</Country><MedlineTA>Dokl Biochem Biophys</MedlineTA><NlmUniqueID>101126895</NlmUniqueID><ISSNLinking>1607-6729</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000903">Antibiotics, Antineoplastic</NameOfSubstance></Chemical><Chemical><RegistryNumber>80168379AG</RegistryNumber><NameOfSubstance UI="D004317">Doxorubicin</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.1.1</RegistryNumber><NameOfSubstance UI="D058570">TOR Serine-Threonine Kinases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber><NameOfSubstance UI="D051057">Proto-Oncogene Proteins c-akt</NameOfSubstance></Chemical><Chemical><RegistryNumber>W36ZG6FT64</RegistryNumber><NameOfSubstance UI="D020123">Sirolimus</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000903" MajorTopicYN="N">Antibiotics, Antineoplastic</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002470" MajorTopicYN="N">Cell Survival</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003587" MajorTopicYN="N">Cytomegalovirus</DescriptorName><QualifierName UI="Q000502" 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PubStatus="entrez"><Year>2020</Year><Month>3</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>3</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>5</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32130607</ArticleId><ArticleId IdType="doi">10.1134/S1607672919060073</ArticleId><ArticleId IdType="pii">10.1134/S1607672919060073</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14182-7</Citation><ArticleIdList><ArticleId IdType="pubmed">16959881</ArticleId></ArticleIdList></Reference><Reference><Citation>Med Microbiol Immunol. 2015 Jun;204(3):409-19</Citation><ArticleIdList><ArticleId IdType="pubmed">25776080</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):E10586-E10595</Citation><ArticleIdList><ArticleId IdType="pubmed">29158406</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Exp Metastasis. 2018 Apr;35(4):309-318</Citation><ArticleIdList><ArticleId IdType="pubmed">29799080</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Russie</li></country><region><li>District fédéral central</li></region><settlement><li>Moscou</li></settlement></list><tree><country name="Russie"><region name="District fédéral central"><name sortKey="Chernoryzh, Ya Yu" sort="Chernoryzh, Ya Yu" uniqKey="Chernoryzh Y" first="Ya Yu" last="Chernoryzh">Ya Yu Chernoryzh</name></region><name sortKey="Fedorova, N E" sort="Fedorova, N E" uniqKey="Fedorova N" first="N E" last="Fedorova">N E Fedorova</name><name sortKey="Gintsburg, A L" sort="Gintsburg, A L" uniqKey="Gintsburg A" first="A L" last="Gintsburg">A L Gintsburg</name><name sortKey="Gintsburg, A L" sort="Gintsburg, A L" uniqKey="Gintsburg A" first="A L" last="Gintsburg">A L Gintsburg</name><name sortKey="Ivanov, A V" sort="Ivanov, A V" uniqKey="Ivanov A" first="A V" last="Ivanov">A V Ivanov</name><name sortKey="Karpov, D S" sort="Karpov, D S" uniqKey="Karpov D" first="D S" last="Karpov">D S Karpov</name><name sortKey="Kornev, A B" sort="Kornev, A B" uniqKey="Kornev A" first="A B" last="Kornev">A B Kornev</name><name sortKey="Kushch, A A" sort="Kushch, A A" uniqKey="Kushch A" first="A A" last="Kushch">A A Kushch</name><name sortKey="Simonov, R A" sort="Simonov, R A" uniqKey="Simonov R" first="R A" last="Simonov">R A Simonov</name><name sortKey="Yurlov, K I" sort="Yurlov, K I" uniqKey="Yurlov K" first="K I" last="Yurlov">K I Yurlov</name><name sortKey="Zakirova, N F" sort="Zakirova, N F" uniqKey="Zakirova N" first="N F" last="Zakirova">N F 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